In der folgenden Übersicht wird versucht, die wissenschaftstheoretischen Tätigkeiten in den Niederlanden, insbesondere auf den Gebieten der Logik und Grundlagenforschung, Philosophie der Naturwissenschaften, Philosophie der Geschichtswissenschaft und der Sozialwissenschaften zu skizzieren. In einer Schlußbetrachtung werden die allgemeinen methodologischen Fragestellungen und die daraus sich ergebenden neuen Möglichkeiten einer Wissenschaftstheorie erörtert.

The development of gene expression profiling and next-generation sequencing technologies have steered oncogenomics to the forefront of precision medicine. This created a need for harmonious cooperation between clinicians and researchers to increase access to precision oncology, despite multiple implementation challenges being encountered. The aim is to apply personalised treatment strategies early in cancer management, targeting tumour subtypes and actionable gene variants within the individual’s broader clinical risk profile and wellbeing. A knowledge-generating database linked to the South African Medical Research Council’s (...) Genomic Centre has been created for the application of personalised medicine, using an integrated service and research approach. Insights gained from patient experiences related to tumour heterogeneity, access to targeted therapies and incidental findings of pathogenic germline variants in tumour DNA, provided practice-changing evidence for the implementation of a cost-minimisation pathology-supported genetic testing strategy. Integrating clinical care with genomic research through data sharing advances personalised medicine and maximises precision oncology benefits. (shrink)

Recent policy developments in the area of livestock husbandry have suggested that, from the perspective of optimizing animal welfare, new animal husbandry systems should be developed that provide opportunities for livestock animals to be raised in environments where they are permitted to engage in “natural behavior.” It is not known whether consumers regard animal husbandry issues as important, and whether they differentiate between animal husbandry and other animal welfare issues. The responsibility for the development of such systems is allocated jointly (...) between farmers, regulators, different actors in the food chain, and consumers. This research focuses on understanding consumer attitudes and preferences regarding the development and introduction of such systems, to ensure that they are acceptable to consumers as well as producers, regulators, and scientists. Consumer perceptions of animal welfare and animal husbandry practices were evaluated using quantitative consumer survey, which focused on two animal husbandry issues – farmed pigs and farmed fish. Following pilot work, 1000 representative Dutch consumers were sampled about their attitudes to either pig or fish husbandry. The results indicated that consumers think about animal welfare in terms of two broad categories related to their health and living environment, but do not think about welfare issues at a more detailed level. Greater concern was expressed about the welfare of pigs compared to fish. Consumer trust in labeling also emerged as an important issue, since consumers need to trust different food chain actors with responsibility for promoting animal welfare, and are reluctant to consider the details of animal husbandry systems. As a consequence, a transparent, enforceable, and traceable monitoring system for animal welfare friendly products is likely to be important for consumers. (shrink)

Introduction: The Dutch Euthanasia Act states that euthanasia is not punishable if the attending physician acts in accordance with the statutory due care criteria. These criteria hold that: there should be a voluntary and well-considered request, the patient’s suffering should be unbearable and hopeless, the patient should be informed about their situation, there are no reasonable alternatives, an independent physician should be consulted, and the method should be medically and technically appropriate. This study investigates whether physicians experience problems with these (...) criteria in medical practice.Methods: In 2006, questionnaires were sent to a random, stratified sample of 2100 Dutch physicians . Physicians were asked about problems in their decision-making related to requests for euthanasia or assisted suicide after enforcement of the 2002 Euthanasia Act.Results: Of all physicians who had received a request for euthanasia or assisted suicide , 25% had experienced problems in the decision-making with regard to at least one of the criteria of due care. Physicians who had experienced problems mostly indicated to have had problems related to evaluating whether or not the patient’s suffering was unbearable and hopeless and whether or not the patient’s request was voluntary or well considered .Discussion: Physicians in The Netherlands most frequently reported problems related to aspects in which they have to evaluate the patient’s subjective perspective. However, it can be questioned whether placing emphasis on these subjective aspects is an adequate fulfilment of the duties imposed on physicians, as laid down in the Dutch Euthanasia Act. (shrink)

The ‘ars inveniendi’ of Cicero has been discussed in studies on Rhetoric, but hardly within the framework of philosophy. This article stresses its importance for philosophical reflection by analysing the ‘ars inveniendi’ in the works of Cicero and tracing its further development (Boethius, Agricola, Ramus). Its effect can be retraced in later philosophers who are using the topic of ‘ars inveniendi’, referring to Cicero, such as Bacon and Leibniz.

Queen pheromones, which signal the presence of a fertile queen and induce daughter workers to remain sterile, are considered to play a key role in regulating the reproductive division of labor of insect societies. Although queen pheromones were long thought to be highly taxon‐specific, recent studies have shown that structurally related long‐chain hydrocarbons act as conserved queen signals across several independently evolved lineages of social insects. These results imply that social insect queen pheromones are very ancient and likely derived from (...) an ancestral signalling system that was already present in their common solitary ancestors. Based on these new insights, we here review the literature and speculate on what signal precursors social insect queen pheromones may have evolved from. Furthermore, we provide compelling evidence that these pheromones should best be seen as honest signals of fertility as opposed to suppressive agents that chemically sterilize the workers against their own best interests. (shrink)

Genomic research results and incidental findings with health implications for a research participant are of potential interest not only to the participant, but also to the participant's family. Yet investigators lack guidance on return of results to relatives, including after the participant's death. In this paper, a national working group offers consensus analysis and recommendations, including an ethical framework to guide investigators in managing this challenging issue, before and after the participant's death.

Optimism has reigned supreme for a long time regarding the potential of education (schooling) to address the many societal ailments that humankind has had to deal with. The outbreak of the COVID-19 pandemic in March 2020 shifted all such aspirations to the back-burner. Now, after just more than a year after the initial outbreak of the pandemic, the question can be raised whether those who managed the pandemic in the educational context followed the correct policies and instituted the correct (ethical, (...) moral) measures in combatting the pandemic. This comparison between the situation in the Netherlands and South Africa reveals that although the role-players in both countries had a good understanding of the situation and of their duties in such conditions, they tended to treat education as just another facet of society, thereby demonstrating a lack of empathy with the unique demands of education (schooling). CONTRIBUTION: In this article, the authors investigate the governance performance of two different countries during the first year of the COVID-19 pandemic concerning education and judge that performance based on a Biblically driven ethical-moral-pedagogical framework. (shrink)

Optimism has reigned supreme for a long time regarding the potential of education (schooling) to address the many societal ailments that humankind has had to deal with. The outbreak of the COVID-19 pandemic in March 2020 shifted all such aspirations to the back-burner. Now, after just more than a year after the initial outbreak of the pandemic, the question can be raised whether those who managed the pandemic in the educational context followed the correct policies and instituted the correct (ethical, (...) moral) measures in combatting the pandemic. This comparison between the situation in the Netherlands and South Africa reveals that although the role-players in both countries had a good understanding of the situation and of their duties in such conditions, they tended to treat education as just another facet of society, thereby demonstrating a lack of empathy with the unique demands of education (schooling). CONTRIBUTION: In this article, the authors investigate the governance performance of two different countries during the first year of the COVID-19 pandemic concerning education and judge that performance based on a Biblically driven ethical-moral-pedagogical framework. (shrink)

Recent results have shown that the relative activation of muscles is different for isometric contractions and for movements. These results exclude an explanation of muscle activation patterns by a combination ofreciprocal and coactivation commands. These results also indicate that joint stiffness is not uniquely determined and that it may be different for isometric contractions and movements.

Leibniz regarded the onomatopœia as the relic of the original and universal language: the language of Adam. He regretted the loss of that „lingua adamica”. This leads to a certain tension between the universality of a new logical language and the specificity of onomatopoeic utterances. This line can also be detected in more recent studies. It is related to the diversity of cultural contexts where performative and narrative language plays a role.

La philosophie de M. Heidegger, encore en plein développement, ne peut pas être présentée dans un simple système. Dans ses dernières publications, M. Heidegger insiste sur la différence et la distance qui existent entre Etre et les « étants » . Pourtant cet Etre a besoin de s'installer en sa vérité dans les « étants ». L'histoire de la métaphysique occidentale est l'histoire de l'oubli de l'Etre, du subjectivisme et du nihilisme. Cette négligence trouve quand même son origine dans l'Etre (...) lui-même. L'Etre est infini et en même temps, dans son essence, fini. M. Heidegger veut ainsi indiquer que la différence entre l'Etre et tout ce qui est ne peut être comprise par une dialectique quelconque. L'Etre se soustrait à la logique de la raison humaine. Il n'est pas un fondement ni un « étant » suprême, ni une base métaphysique), mais un processus mystérieux de s'ouvrir, c'est-àdire arriver et disparaître dans l'horizon du temps. Quand l'homme se vainc comme subjectivité, il se place dans cette ouverture, cette transcendance pure qui manifeste l'Etre. Il surmonte les « étants » délimités, se rendant compte de leur stabilité falacieuse. Ici, tout ce qui est se montre dans sa particularité, dans le secret de sa contingence et se trouve ainsi dans le cercle lumineux de l'Etre. (shrink)

La métaphysique de Berkeley présente une synthèse des méthodes analytique et phénoménologique et sa pensée peut être considérée à cet égard, comme le pont entre la philosophie contemporaine du continent et la philosophie anglo-saxonne. C'est pour cela que des penseurs comme Husserl, Wittgenstein, Wisdom, Ryle et d'autres sont mentionnés dans l'article. La métaphysique procure à Berkeley Ja condition transcendentale de telles méthodes. L'analyse du langage élimine les sentences de la métaphysique spéculative. Quand on dit par exemple qu'un dé est dur, (...) carré, etc., cela n'implique pas que ces qualités sont des propriétés d'une substance inconnue, mais elles ne sont que l'explication de ce qu'on entend par l'existence du dé. Berkeley ne veut pas supprimer l'existence, mais rendre le terme explicite. Son analyse découvre que le mot existence est employé lorsqu'on aperçoit quelque chose. L'idée de l'existence d'un paysage non perçu est une image où l'homme se supprime comme observateur. Berkeley ne s'efforce pas de suppléer les intervalles , en supposant Dieu comme observateur permanent. Il part plutôt du langage quotidien où il va de soi que les choses continuent d'exister, même sans être perçues. Cette réalité ne dépend apparemment pas de l'homme individuel et elle renvoie donc vers Dieu, l'existence n'étant rien en soi-même, autrement le mot serait dénué de sens. Les « idées » sont chez Berkeley les choses elles-mêmes et non leur copie dans l'esprit comme chez Locke. Le mot idée indique que leur existence est conçue comme processus de vérification. Berkeley analyse d'une même manière « opérationnelle » les conceptions mathématiques. Le triangle n'est qu'une convention par définition à l'égard de l'utilisation de ce symbole. Les lois de la nature sont une grammaire de la nature qui indique les régularités extérieures et non les forces occultes. Le point de départ de sa méthode que l'on peut appeler phénoménologique est la perception attentive de sa propre conscience. C'est là que les idées se manifestent comme les choses elles-mêmes dans leur présence corporelle. Husserl reconnaît ici son propre effort d'une constitution de la « mondanité » . Berkeley offre une phénoménologie de la perception dans laquelle le monde extérieur manifeste un rapport à la subjectivité. Le temps également trouve sa source dans son rapport à l'esprit. C'est ainsi que Berkeley combat l'objectivisme des sciences naturelles. L'esprit et ses « notions » ne sont comme principe actif, pas à comparer avec les choses .Berkeley, par opposition à la conception des facultés de l'âme, dit que la volonté, la haine, l'amour etc., sont des orientations de l'esprit qui se manifestent aux objets et aux situations. L'objectivité corporelle est un modèle de la subjectivité de l'esprit. métaphysique de Berkeley ne donne pas une compréhension des faits nouveaux, mais une nouvelle compréhension des faits ; elle ne crée pas un arrière-monde, mais elle dévoile l'horizon de sens de ce monde-ci. C'est pour cela qu'elle n'est pas réductrice. La matière n'est pas réduite à l'esprit, mais elle est plus riche que la conception objectiviste de la matière, n'existant que dans une cohésion de signification avec l'esprit. Le monde devient langage dont le sens est de renvoyer vers Dieu ; Dieu est l'auteur, non la cause première. Il est inconnaissable comme objet étant le sujet à partir duquel le dessein du langage et la grammaire de la nature deviennent lisibles. Ici, il ne s'agit plus d'un langage purement théorique mais pratique, qui dévoile le sens du monde en le rendant tendancieux. (shrink)

We often give culture a narrow definition, confining it to the sum of works of art or of science, and to institutions such as universities, middle schools, primary schools, and museums, and to language, civilized behavior, and the social superstructure. Under the influence of cultural anthropology, we have already come to accept a broader concept of culture, and that is that culture is the sum of the activity of humankind in accordance with a certain intention to transform nature or the (...) things of nature. In this sense, agriculture, dance, physical drills , education, the processes of economic activity, and ancient traditions all would belong to the category of culture. In life, even activities such as eating and sleeping are no longer considered purely natural behavior because they are different from the eating or sleeping of animals; rather, they have been transformed by culture, their shapes and states have been changed. For example, the way in which the Chinese people eat is different from the way that Europeans, or Americans, eat. The emphasis of this new and broader definition of culture is no longer on things; culture is no longer defined in reference to objects such as the products of a museum or a scientific product, but to an activity, such as a dance performance, or some form of cultural heritage in an ancient or a modern society. We can therefore draw a conclusion that the term "culture" is no longer a noun, referring to some kind of substance, but is a verb, and points to a process. (shrink)

Although law is established on a strong presumption that persons younger than a certain age are not competent to consent, statutory age limits for asking children’s consent to clinical research differ widely internationally. From a clinical perspective, competence is assumed to involve many factors including the developmental stage, the influence of parents and peers, and life experience. We examined potential determining factors for children’s competence to consent to clinical research and to what extent they explain the variation in competence judgments.

Patients in a vegetative state/ unresponsive wakefulness syndrome (VS/UWS) pose ethical dilemmas to those involved. Many conflicts occur between professionals and families of these patients. In the Netherlands physicians are supposed to withdraw life sustaining treatment once recovery is not to be expected. Yet these patients have shown to survive sometimes for decades. The role of the families is thought to be important. The aim of this study was to make an inventory of the professional perspective on conflicts in long-term (...) care of patients in VS/UWS. A qualitative study of transcripts on 2 Moral Deliberations (MD’s) in 2 cases of patients in VS/UWS in long-term care facilities. Six themes emerged: 1) Vision on VS/UWS; 2) Treatment and care plan; 3) Impact on relationships; 4) Feelings/attitude; 5) Communication; 6) Organizational aspects. These themes are related to professionals and to what families had expressed to the professionals. We found conflicts as well as contradictory feelings and thoughts to be a general feature in 4 of these themes, both in professionals and families. Conflicts were found in several actors: within families concerning all 6 themes, in nurse teams concerning the theme treatment and care plan, and between physicians concerning all 6 themes. Different visions, different expectations and hope on recovery, deviating goals and contradictory feelings/thoughts in families and professionals can lead to conflicts over a patient with VS/UWS. Key factors to prevent or solve such conflicts are a carefully established diagnosis, clarity upon visions, uniformity in treatment goals and plans, an open and empathic communication, expertise and understanding the importance of contradictory feelings/thoughts. Management should bridge conflicts and support their staff, by developing expertise, by creating stability and by facilitating medical ethical discourses. Shared compassion for the patient might be a key to gain trust and bridge the differences from non-shared to shared decision making. (shrink)

Bacon is not an empiricist. His critique concerns equally sense-experience and conceptformation. He uses the term „experience” in a wider sense, closely related to „wisdom”. Bacon is not an inductionist. The falsification-principle is explicit in his philosophy. The new meaning of „induction” in Bacon implies that judgements are not mainly guided by the presence of phenomena but by their absence. Bacon is not het precursor of modern science as regards their contents. He has been, on this point, too much influenced (...) by Renaissance natural magic. Bacon anticipates, however, modern sciences with regard to their method. The central issue of his philosophy is, according to his own words, the „ars inveniendi”. In modern terminology: the context of discovery is the main objective of his new methodology. (shrink)

This paper attempts to systematically characterize critical reactions in argumentative discourse, such as objections, critical questions, rebuttals, refutations, counterarguments, and fallacy charges, in order to contribute to the dialogical approach to argumentation. We shall make use of four parameters to characterize distinct types of critical reaction. First, a critical reaction has a focus, for example on the standpoint, or on another part of an argument. Second, critical reactions appeal to some kind of norm, argumentative or other. Third, they each have (...) a particular illocutionary force, which may include that of giving strategic advice to the other. Fourth, a critical reaction occurs at a particular level of dialogue (the ground level or some meta-level). The concepts here developed shall be applied to discussions of critical reactions by Aristotle and by some contemporary authors. (shrink)

The article points out the implications of the discovery of the structure of desoxyribonuceine-acid for the philosophical study of man. The DNA contains in the chromosomes the genetic information. It contains a code which is being deciphered by the way the „instructions”, contained by the specific order of elements of the DNA, are realised by the whole organisation of the organism. In the course of evolution these instructions are becoming more specific and more complex, resulting in the organisation of the (...) human organism. The mutations that feed evolution can be considered, on the one hand as noise, on the other hand as a possibility for readaptation to the environment. In such a readaptation the higher organisms are giving more specific responses, in the human being even responses not at the first place to stimuli, but to the meaning those stimuli convey. A philosophy of man can, from this point of view, consider the human body not so much as a machine or as a material substance, but as a form of organisation making extensive implied genetic information. Human being has the character of an information-structure which, in the course of time, becomes more specific, more „meaningful” in its responses. What is called in philosophy „spirit” or „consciousness” is human being in its structure of an open system, readapting its own information - genetic and sociocultural ones - to the meaning manifested to him by his environment, his history and his social tasks. (shrink)